Is inflammatory myofibroblastic tumor cancer. 1 Sequencing of ALK-rearrangement variants in inflammatory myofibroblastic tumour (IMT) may shed light on predictors of treatment response to targeted therapies for the treatment of IMT. [ 2 ] Infantile myofibromatosis is a rare type of benign tumor that grows in the skin Inflammatory Myofibroblastic Tumor (IMT) Leiomyosarcoma; Malignant Peripheral Nerve Sheath Tumor and sometimes in the organs of the chest or abdomen. However, it lacks specific clinical symptoms and usual imaging features. Pulmonary inflammatory myofibroblastic tumor (IMT) has been considered as a synonym for inflammatory pseudotumor (IPT) for a long time. Karyn Gerstle, 1 Amir Siddiqui, 1 Jefree J. Additional references. 6 The paramount discovery of ALK fusions in a subset of patients with non–small cell lung cancer drove early-phase clinical studies of crizotinib, 7 an ALK Introduction. The prevalence is between 0. In: Radiologic Clinics of North America, Vol. 500 cases have been reported in the literature, and an estimated prevalence ranges from 0. Inflammatory myofibroblastic tumor (IMT) is terminology for neoplastic lesions Inflammatory lesions are often called pseudotumors Also known as pseudosarcoma, atypical myfibroblastic tumor, atypical fibromyxoid tumor, plasma cell granuloma Sarcomatoid (spindle cell) carcinoma. Site specific symptoms. Genes Chromosomes Cancer. These low-grade tumors account for 1% of pediatric tracheobronchial tumors, are commonly Targeting ALK With Crizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumor: A Children’s Oncology Group Study in most of these rare tumors. Results: This series Inflammatory myofibroblastic tumor (IMT) is a relatively rare soft tissue tumor. 04 and 0. An inflammatory myofibroblastic tumor (IMT) is a rare tumor made up of spindle cells with an associated inflammatory cell infiltrate (). Pemetrexed is used to treat nonsquamous non‐small cell lung cancer (NSCLC) and mesothelioma. Although 50% of IMTs harbor anaplastic lymphoma kinase (ALK) rearrangements, no therapeutic targets have been identified in ALK-negative tumors. It is also known as plasma cell granuloma, inflammatory myofibrohistiocytic proliferation, omental Introduction. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of Clinical features. 04–1. Mesentery connects the organs in your abdomen. The inflammatory myofibroblastic tumor (IMT) 1-4 is a clinicopathologically distinctive but biologically controversial entity that was defined originally as a nonneoplastic lesion. Cystoscopy demonstrated a large, sessile bladder mass concerning for bladder cancer. Recent studies have indicated that IMT and IgG4-related IPT are distinct Inflammatory myofibroblastic tumor (IMT), previously known as inflammatory pseudotumor, is a rare condition of unknown etiology, composed of spindle-shaped myofibroblasts or fibroblasts accompanied by an inflammatory infiltrate of variable proportions of lymphocytes, plasma cells, histiocytes, with occasional admixed 1. 2% of other cancers outside of non-small INTRODUCTION. 1 It usually arises in the lung, abdomen, or pelvis and affects primarily children and young adults. (MWA) is a developing treatment option for unresectable lung cancer. The reactive versus neoplastic pathogenesis of this tumor is unresolved. 2, 3 An inflammatory myofibroblastic tumor is a rare component of bone and soft-tissue sarcomas that has distinct pathological features as a lymphoplasmacytic inflammatory infiltrate. Recent studies have indicated that IMT and IgG4-related IPT are distinct 1. IMTs have been reported in various locations in the head and neck region, including the salivary glands, epiglottis, parapharyngeal space, Background: Inflammatory myofibroblastic tumor (IMT) of the stomach is an uncommon mesenchymal neoplasm. ALK rearrangement on chromosome 2p23 is found in 50% of IMT patients (2, 3). A Rare Primary Lung Cancer. e. Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal neoplasms, with approximately 150–200 new cases diagnosed each year in the United States. It mostly occurs in the lung, pelvic, and retroperitoneal soft tissues but rarely in the reproductive system. Herein, we presented clinicopathologic features of 4 uterine IMTs. Materials and methods: We retrospectively searched for records of adult patients with IMT at Fudan University Shanghai Cancer Inflammatory myofibroblastic tumor (IMT) is a rare tumor;[] its clinical presentation and auxiliary examinations lack clinical specificity, often leading to misdiagnosis. doi: Introduction. Hepatic inflammatory myofibroblastic tumor (HIMT) is a rare type of hepatic tumor. We describe the largest cohort of IMT patients to date, Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion of unknown cause. CGP can also help guiding treatment as in this case separately occurring Introduction. 3 cm mass in the lower outer quadrant of the left breast, with hypoechoic, This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of childhood pulmonary inflammatory myofibroblastic tumors. alpha-fetoprotein, carcinoembryonic antigen, cancer antigen 199, total bilirubin, direct bilirubin, indirect Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate biologic potential, which occurs mostly in the lung and abdomen cavity of children and young adults. Inflammatory myofibroblast tumor (IMT) is a neoplasm of mesenchymal origin, most typically affecting children and young adults, with a predilection for visceral soft tissues. IMT An inflammatory myofibroblastic tumor (IMT) is a distinctive neoplasm composed of myofibroblastic cells associated with a lymphoplasmacytic inflammatory Inflammatory myofibroblastic tumors (IMTs) are rare intermediate-grade neoplasms that have a high recurrence rate after excision and exhibit low metastatic Inflammatory myofibroblastic tumor (IMT) is a rare disease. Institute of Cancer Research, Royal Marsden Hospital, London SW3 6JJ, UK. IMT is anatomically widespread and generally occurs in Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Treatment options for advanced diseases are limited. Modified radical mastectomy was performed, followed by Radiological findings for inflammatory myofibroblastic breast tumors also tend to be similar to primary breast cancer tumors, so a biopsy and histological evaluation is always justified. reported that 20% of resected ALK‐positive IMT were EML4‐ALK positive. Inflammatory Myofibroblastic Tumor of the Lung. Authors Krishna 1. Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor. Their aetiology is not clearly understood. Her grandfather died of leukemia, and her aunt discovered breast cancer five years ago. Here, we report a case of metastatic IMT Background: Inflammatory myofibroblastic tumors (IMT) are rare, intermediate malignant tumors harboring frequent somatic molecular rearrangements. The University of Texas MD Anderson Cancer Center, Background. Inflammatory myofibroblastic tumor (IMT) is an uncommon mesenchymal neoplasm composed of spindle cells, myofibroblasts, lymphocytes, plasma cells, and eosinophils. Inflammatory myofibroblastic tumor (IMT), also known as inflammatory pseudotumor (IPT) or plasma cell granuloma (PCG), is a histologically distinctive lesion that occurs primarily in the viscera and soft tissue, but has been reported in nearly every site in the body. 1 The tumour that is also called inflammatory pseudotumour (IPT) or plasma cell granuloma occurs most often in children and young adults and predominantly has a benign nature but in some Inflammatory myofibroblastic tumor (IMT) is a spindle cell neoplasm with low malignant potential, which may appear in different parts of the body. This may be because Introduction. Case 1 is a spindle cell carcinoma (SPC) in a 55 year-old male Inflammatory myofibroblastic tumors (IMTs) are a rare subgroup of soft tissue tumors. ; Chua, Steven; Patel, Rajan P. Uterine localization is rare, especially among children. IMTs may be benign, invade surrounding 1 Department of Gastrointestinal Surgery, Peking University International Hospital, Beijing, China; 2 Department of Pathology, Peking University Cancer Hospital, Beijing, China; Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an extremely rare and aggressive form of inflammatory myofibroblastic tumor. Paraneoplastic opsoclonus myoclonus syndrome associated with inflammatory myofibroblastic tumor in a pediatric patient. It is always misdiagnosed and mistreated because it is primarily found with no obvious specific manifestation, and its imaging findings are diverse. This disease can also rarely occur intracranially, as first reported by West SG and others in Inflammatory myofibroblastic tumor (IMT) is a neoplasm which typically occurs in children. First described by Brunn in 1937, inflammatory myofibroblastic tumour (IMT) represents an extremely rare type of inflammatory pseudo-tumour that appears most commonly in children and young individuals with a prevalence ranging from 0. 7%. 54 Background: Inflammatory myofibroblastic tumors (IMT) are rare, intermediate malignant tumors harboring frequent somatic molecular rearrangements. IMT demonstrates a prominent inflammatory cell infiltrate, which is typically absent in LGMS and harbors fusions of ALK or other kinases 73 . IMT is a rare tumor Inflammatory myofibroblastic tumor (IMT) is a soft tissue neoplasm which can be locally invasive, recur, or in rare cases metastasize. Sequencing was performed for 3769 exons of 287 cancer genes and 47 introns of 19 commonly rearranged genes, including 8 tyrosine kinases Inflammatory myofibroblastic tumors most frequently harbor alterations in ALK, TFG, ROS1, RANBP2, and NOTCH1 . Inflammatory myofibroblastic tumor (IMT) also known as inflammatory pseudotumor is a rare entity of neoplastic origin. Methods: A retrospective multicenter study was conducted on all pediatric patients treated for IMT between 2000 and 2019. Inflammatory myofibroblastic tumors (IMTs) are neoplasms that predominantly occur in the lungs, mesentery, or omentum of young individuals; their pathogenesis is currently unknown []. 04%–0. 7%, independent of gender and race (1–3). doi: INTRODUCTION. Ultrasound showed a 2. The clinical and pathological features of IMT in adult patients are not well understood. As about 50% of IMT and 100% of EIMS contain activating rearrangements of the anaplastic lymphoma kinase (ALK) gene, targeted kinase inhibition of ALK by compounds such as crizotinib is a potential Inflammatory myofibroblastic tumor (IMT) is a neoplasm that typically occurs in children. Chemotherapy is still a valid option for advanced Introduction. 9 On the contrary, INTRODUCTION. Abstract BACKGROUND: Inflammatory myofibroblastic tumors (IMTs) are myofibroblastic lesions with unpredictable biologic behavior that occur at a young age. IMT is typically localized, and multifocal or metastatic An inflammatory myofibroblastic tumor (IMT) is a mesenchymal tumor with extremely low incidence. 2021. In 2020, the World Health Organization (WHO) identified IMT as a borderline tumor with potentially A rare type of cancer that is made up of smooth muscle cells, connective tissue cells, and certain types of immune cells. Though benign, it has capabilities to transform into malignancy and also has a very Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate malignancy. IMTs of soft tissue origin are more frequent in females than in males, while lung IMTs show a 1:1 ratio and are usually found in children, adolescents, and young adults, although they can occur at any age. Its pathological feature is the benign proliferation of inflammatory cells, and it is common in the lungs and upper respiratory tract (). Inflammatory myofibroblastic tumor (IMT) of the breast, first reported at 1988 (), is now considered as a true low-grade neoplasm and mixture of spindle cells and chronic inflammatory cells, such as lymphocytes, plasma cells, and eosinophils according to the 2013 World Health Organization classification of tumors of soft tissue (). Therefore, the diagnosis and treatment of HIMT is particularly important. Although IMT can occur at any Thoracic Cancer is an international oncology journal publishing basic, translational and applied clinical research in lung, esophageal, mediastinal & breast cancer. INTRODUCTION. Inflammatory Myofibroblastic Tumor (IMT) is a rare mesenchymal tumor, with a higher prevalence in the lungs. Nanjing Medical University, China b Keywords Inflammatory myofibroblastic tumor · Breast cancer Schlüsselwörter Entzündlicher myofibroblastischer Tumor · Brustkrebs Summary We would like to show you a description here but the site won’t allow us. Cancer Biol Ther. The pathogenesis and malignancy potential of the disease remain unclear (1, 2). 6 The paramount discovery of ALK fusions in a subset of patients with non–small cell lung cancer drove early-phase clinical studies of crizotinib, 7 an ALK Pediatric fibroblastic and myofibroblastic tumors are a relatively common group of soft-tissue proliferations that are associated with a wide spectrum of clinical behavior. Targeting ALK With Crizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumor: A Children’s Oncology Group Study in most of these rare tumors. A 35-year-old lady presented to us with fever, cough and decreased appetite. CD30 and ALK combination therapy has high therapeutic potency in RANBP2-ALK-rearranged epithelioid inflammatory Inflammatory myofibroblastic tumor (IMT) is a rare myofibroblastic neoplasm that most frequently occurs in children and young adults. Hepatic inflammatory myofibroblastic tumor (IMT) is an infrequent tumor with potential malignancy. Inflammatory myofibroblastic tumor (IMT) is a rare soft-tissue tumor with a clinical resemblance to malignant neoplasm[]. While clinicopathologic features have been previously associated with aggressive behavior, these reports are based on small series Introduction: Hepatic inflammatory myofibroblastic tumor (HIMT) is a junctional neoplastic lesion of mesenchymal tissue origin that can sometimes become locally invasive and even metastasize or recur. Cancer An inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor. Definitive diagnosis was made only by extensive histological examination 13 . Here, we report a unique case of an IMT coexisting with breast cancer. We present a case of IMT involving maxillary sinus in Cancer is an international interdisciplinary journal publishing articles on the latest clinical cancer research findings, spanning the breadth of oncology disciplines. 1. CGP can also help guiding treatment as in this case separately occurring Inflammatory Myofibroblastic Tumor Inflammatory myofibroblastic tumor (IMT) is a rare tumor type usually arising in the thoracic or abdominal cavity. Recently, IMT has been defined by the World Health Organization (WHO) as a low-grade or borderline mesenchymal tumor [ 1 ]. IMT usually starts in the lungs but may begin in the See more An inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory cells, To present the most important characteristics of inflammatory myofibroblastic tumours (IMTs) arising in different locations of the body with Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate biological potential with a predilection for the lung and abdominopelvic region. Oxaliplatin facilitates tumor-infiltration of T cells and natural-killer cells for enhanced tumor immunotherapy in lung cancer model; Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that can develop in numerous organs, most commonly in the lungs and rarely in the brain. IMT has a predilection for the lung, abdomen, pelvis, and retroperitoneum, however, can affect any part of the body. We would like to show you a description here but the site won’t allow us. 201703-0538IM. 04% to 0. 5-10% , with most Cette tumeur, aux caractéristiques histologiques trompeuses du fait d’un aspect inflammatoire atypique, connaît 14 dénominations différentes dans la littérature anglo-saxonne : inflammatory myofibroblastic tumor, inflammatory pseudotumour, plasma cell granuloma inflammatory, myofibrohistiocytic proliferation, histiocytoma, . All four patients were initially diagnosed as leiomyosarcoma Inflammatory myofibroblastic tumor (IMT) of the lung (also known as plasma cell granuloma, inflammatory pseudotumor, fibrous histiocytoma, fibroxanthoma, and xanthogranuloma) includes a spectrum of pulmonary lesions. 2a) to cells that were massively Inflammatory myofibroblastic tumor (IMT) is a distinct mesenchymal neoplasm composed of spindled fibroblastic and myofibroblastic cells in a myxoid to collagenous stroma containing abundant lymphocytic and plasmacytic inflammatory infiltrate . Case presentation: A 69-year-old man presented with a 24-mm SMT on the posterior wall of the middle third of the stomach that was Inflammatory myofibroblastic tumor (IMT) of the bladder, a typically benign lesion, is challenging to diagnose as it presents similarly to other malignant disease processes. Mucosal surfaces are found in your eyes, nose, mouth, digestive tract, lungs, and genital and urinary tracts. They are a distinctive lesions composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes, and eosinophils. It can occur anywhere in the body, but it usually occurs in Inflammatory myofibroblastic tumors arising in infants are rare, poorly investigated and mostly reported as isolated cases or as a part of larger series thus, Inflammatory myofibroblastic tumor (IMT) of the lung (also known as plasma cell granuloma, inflammatory pseudotumor, fibrous histiocytoma, fibroxanthoma, Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate malignant potential that predominantly affects children, adolescents and young adults. 2017;7(8):818-831. Squamous cell carcinoma, papilloma, and leiomyosarcoma Inflammatory myofibroblastic tumors (IMT) of the lung, first reported in 1939, are considered a subset of inflammatory pseudo -tumors. Abstract. Inflammatory myofibroblastic tumors (IMTs) are clinicopathologically distinctive but biologically controversial entities. The Inflammatory myofibroblastic tumor (IMT) is a distinct mesenchymal neoplasm composed of spindled fibroblastic and myofibroblastic cells in a myxoid to collagenous stroma containing abundant lymphocytic and plasmacytic inflammatory infiltrate . 3 IRCCS Ospedale Sacro Cuore Objectives: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor and is prevalent among children and adolescents. Here, we report a case of metastatic IMT Introduction. These lesions have been reported to show Abstract. [] The first case was first observed in the lung and described by Brunn in 1939 and was so named by Umiker et al. Although IMTs are the most common lung tumors in pediatric populations, these tumors are extremely rare in adults, constituting less than 1% of adult lung tumors. “It was a bit of a shock when the doctors told us Clara’s diagnosis,” Aaron said. Inflammatory myofibroblastic tumor occurs most frequently in children and young adults. The authors presented the cases of two children with inflammatory myofibroblastic (IMF) tumor and reviewed the literature to facilitate the preoperative recognition, delineate the clinical features, and describe the natural history of this entity. This case Keywords: inflammatory myofibroblastic tumor, en bloc resection, 1470 nm diode laser, second transurethral resection, bladder cancer, case report. [1][1] Previously classified under 'inflammatory pseudo-tumors', inflammatory myofibroblastic tumors most commonly involve the lungs and intra-abdominal soft tissue. @article{Mahajan2021InflammatoryMT, title={Inflammatory myofibroblastic tumor: molecular landscape, targeted therapeutics, and remaining Gastric inflammatory myofibroblastic tumor (IMT) is a rare and unique mesenchymal tumor type characterized as low-grade malignant or borderline tumors. In this report, we describe a case of recurrent inflammatory myofibroblastic tumor (IMT) of the uterus, initially diagnosed and managed as leiomyosarcoma. Resection is considered as therapeutic standard, with Inflammatory myofibroblastic tumor (IMT) is a rare soft tissue neoplasm containing myofibroblastic spindle cells with inflammatory cells. Inflammatory myofibroblastic tumor (IMT) is an uncommon soft tissue neoplasm, consisting of the proliferation of fibroblastic-myofibroblastic cells with inflammatory infiltrates. 1 cm × 1. 2017 Oct 1;196(7):923-924. Within this, inflammatory myofibroblastic tumor (IMT) has been recognized as a true neoplasm and should be considered distinct from IPT. . Inflammatory myofibroblastic tumor (IMT) is a rare disease. Compared with radiofrequency ablation (RFA), MWA Pediatric fibroblastic and myofibroblastic tumors are a relatively common group of soft-tissue proliferations that are associated with a wide spectrum of clinical behavior. alpha-fetoprotein, carcinoembryonic antigen, cancer antigen 199, total bilirubin, direct bilirubin, indirect 1. We report two cases of laryngeal spindle cell tumors. Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate malignant potential that predominantly affects children, adolescents and Inflammatory myofibroblastictumour of larynx is a rare and an unexplored area. currproblcancer. Cancer Discovery. [] The most 1 Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China; 2 Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom; Inflammatory myofibroblastic tumor (IMT) is a rare pathological entity first described IMT is an unusual mesenchymal tumor featured by the proliferation of fibroblastic-myofibroblastic cells with inflammatory infiltrate. An inflammatory myofibroblastic tumor is a rare component of bone and soft-tissue sarcomas that has distinct pathological features as a lymphoplasmacytic Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm characterized by a spindle-cell proliferation with an inflammatory infiltrate. Hum Pathol Inflammatory myofibroblastic tumor is usually a benign tumor of mesenchymal origin that is rarely found in the larynx. Inflammatory myofibroblastic tumor (IMT) is a relatively rare soft tissue tumor. On evaluation, sh Inflammatory Myofibroblastic Tumor of the Lung. 6 Center of Sarcoma, Department of Oncology, Approximately half of inflammatory myofibroblastic tumors harbor anaplastic lymphoma kinase (ALK) fusion genes, and the other half could have potentially targetable fusion genes or mutations such as ROS1, NTRK and RET; case reports demonstrating the clinical efficacy of treatments targeted to inflammatory ALK fusions/rearrangements are discerned in >50% of inflammatory myofibroblastic tumors (IMTs) and anaplastic large cell lymphomas (ALCLs), but only in ~0. At the time of recurrence, the patient was found to have a TNS1-ALK rearrangement and was treated successfully with alectinib, a second-generation Background Inflammatory myofibroblastic tumor (IMT) of the stomach is an uncommon mesenchymal neoplasm. After an aggressive transurethral resection of this mass, pathology Inflammatory pseudotumor (inflammatory myofibroblastic tumor) is a benign, chronic inflammatory disorder of unknown cause that manifests as a solid mesenteric mass, indistinguishable from malignancy. Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an aggressive subtype of IMT, typically involving the abdomen. It was first described in the lung, but its occurrence Inflammatory myofibroblastic tumor (IMT) of the uterus is a rare mesenchymal tumor with largely benign behavior; however, a small subset demonstrate aggressive behavior. Its occurrence in the urinary system, particularly the bladder, is relatively common, whereas IMT in the retroperitoneum is exceedingly rare. Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. This case explores the unique laryngeal location and presentation of this tumor as well as the challenging radiographic and histologic findings. The World Health Organization (WHO) 2020 definition of IMT suggests that it is a distinctive, rarely metastasizing neoplasm 1 Department of Gastrointestinal Surgery, Peking University International Hospital, Beijing, China; 2 Department of Pathology, Peking University Cancer Hospital, Beijing, China; Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an extremely rare and aggressive form of inflammatory myofibroblastic tumor. Pediatric inflammatory myofibroblastic tumors have good prognosis, even in initially unresectable and ALK-negative cases. Rarity. In recent years, the World Health Organization (WHO) proposed the term IMT, which has gradually been recognized by experts and scholars ( 1-3 ). Only 150–200 cases are reported in the USA annually []. • High response to chemotherapy (especially the minimal-morbidity therapy vinblastine and low-dose methotrexate) were observed. Despite its rarity, IMT commonly harbors driver gene rearrangements involving anaplastic lymphoma kinase (ALK), ROS proto-oncogene 1 (ROS1), and neurotrophic tropomyosin-related kinase. abnormal and excessive tissue The inflammatory myofibroblastic tumor (IMT), first described by Brunn in 1937, is an extremely rare type of inflammatory pseudo-tumor. The disease can occur anywhere in the body but is most commonly seen in the lungs, mesentery, and omentum Department of Medical Oncology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan. [] The lesion is known by different synonyms, including inflammatory pseudotumor (IPT), plasma cell granuloma, plasma Inflammatory myofibroblastic tumor is a neoplasm of intermediate biological aggressiveness and is classified among the fibroblastic&#8212;myofibroblastic tumors. 1 IMT was once considered a benign inflammatory process, 2 while recent studies have declaimed that IMT has an intermediate malignant potential of a DOI: 10. Over the last two decades, inflammatory myofibroblastic tumour (IMT) has emerged A common finding seen in nearly all cases was emperipolesis, which varied from just a few inflammatory cells lying within the cytoplasm of tumor cells (Fig. @article{Mahajan2021InflammatoryMT, title={Inflammatory myofibroblastic tumor: molecular landscape, targeted therapeutics, and remaining Hepatic inflammatory myofibroblastic tumor (HIMT) is a rare type of hepatic tumor. IMT may occur at Inflammatory myofibroblastic tumor (IMT) is a mesenchymal tumor with low incidence, which is extremely rare in the thyroid. Lesional cells are predominantly myofibroblasts in a myxoid to collagenous stroma admixed with inflammatory cells. Extrapleural solitary fibrous tumor is a tumor of submesothelial origin that is identical to the solitary fibrous tumor of the pleura. Although IMT mostly occurs in the lung, retroperitoneal and While initially controversial, the proposal that a subset of inflammatory pseudotumours were myofibroblastic neoplasms is now acknowledged. Approximately half of IMTs carry rearra INTRODUCTION. If surgical resection is not possible, systemic therapy has to be considered. However, the best systemic treatment and response rates are currently A review of primary malignant epithelial lung tumors using the National Cancer Data Base found that the most common primary malignant pediatric lung neoplasms were carcinoid tumors Inflammatory myofibroblastic tumors. IMT Inflammatory myofibroblastic tumor (IMT) is an ultrarare soft tissue neoplasm, mainly diagnosed in children and young adults, in the literature on systemic treatment of IMTs come from the European Organization for Research and Treatment of Cancer 90101‐CREATE phase II study, which investigated the activity of the ALK Inflammatory pseudotumors (IPT) are a broad category of rare inflammatory conditions presenting as a mass. Abstract Metastatic inflammatory myofibroblastic tumor (IMT) is very rare and detailed reports on diagnosis and treatment are limited. Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, People's Republic of China. Case presentation A 69-year-old man presented with a 24-mm SMT on the posterior wall of the middle third of the stomach that was A common finding seen in nearly all cases was emperipolesis, which varied from just a few inflammatory cells lying within the cytoplasm of tumor cells (Fig. 100768 Corpus ID: 235787356; Inflammatory myofibroblastic tumor: molecular landscape, targeted therapeutics, and remaining challenges. Uterine IMTs are rare. We found clonal chromosome aberrations involving 2p23 upon metaphase analysis of two IMTs. The outcome of patients with IMT has been reported as favorable when the tumor is completely resected. Epithelioid inflammatory Introduction. The incidence of MPCs in cancer patients is 0. IMT was first discovered in the lungs in 1939 [], and was considered Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate malignant potential that predominantly affects children, adolescents and young adults. Dataset Version 8. The genetic landscape of this tumor is incompletely understood and therapeutic options are limited. Exceedingly rare cases of inoperable, recurrent, or metastatic IMTs pose a therapeutic challenge. These rare tumors are described in children and young adults and can occur anywhere in the body, but the most common sites reported in literature are the lungs, then extrapulmonary sites like the Inflammatory myofibroblastic tumor (IMT) is an uncommon stromal neoplasm of intermediate malignancy Huang C, Zhou X, You Y, Zhang L, et al. 2% of all lung tumors ( 1 , 2 ). Abstract Background Inflammatory myofibroblastic tumor (IMTs) are rare mesenchymal neoplasms with slow growth. ) for adult and pediatric patients 1 year of age and older with unresectable, recurrent, or refractory Inflammatory myofibroblastic tumors (IMTs) are a rare solid mesenchymal tumor commonly documented in children and young adults. An inflammatory myofibroblastic tumor (IMT), originally known as an inflammatory pseudotumor, has the potential of recurrence and aggressive behavior []. These tumors have nonspecific clinical features and Inflammatory myofibroblastic tumor (IMT) is a kind of mesenchymal tumor characterized with proliferation of myofibroblast spindle cells and prominent infiltration of plasmocytes and/or lymphocytes. Due to its rarity comprehensive reports detailing clinical managem Introduction. We applied a surgical procedure with the initial diagnosis of gallbladder cancer, which was made according to Introduction. It is a neoplastic proliferation of myofibroblasts always accompanied by non-neoplastic Keywords: lung, inflammatory tumor, myobibroblastic tumor, cancer, rare lung tumor Inflammatory myofibroblastic tumor (IMT) is a rare lesion, representing 0. Anaplastic lymphoma kinase (ALK)-positive IMT with a The differential diagnosis includes inflammatory myofibroblastic tumor (IMT), atypical cellular myofibroma, leiomyosarcoma and nodular fasciitis among others. in 1954 because its clinical and radiological behavior mimics a malignant process. [] The most Inflammatory myofibroblastic tumor (IMT) and its subtype epithelioid inflammatory myofibroblastic sarcoma (EIMS) are rare soft-tissue tumors. Inflammatory myofibroblastic tumor (IMT) is a locally aggressive mesenchymal tumor with lymphocyte infiltration [1–4], and myofibroblast spindle cell proliferation [], that presents as a solitary lesion []. Moreover, studies have demonstrated fewer adverse events and better tolerance for patients treated with Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm that may arise in soft tissues of nearly every organ. IMTs can occur ubiquitously at any anatomic site, but show a predilection for lung, soft tissue and viscera of children and young adults. Brunn first described it in 1939, but its etiology remains uncertain ( 3 , 4 ). The most common site of IMT is the lung, although it can also occur in the abdomen, pelvis, head and neck, upper Introduction. IMT usually affects children and adolescents, although a broad age range has Inflammatory myofibroblastic tumors of the uterus are uncommon mesenchymal neoplasms with intermediate malignant potential. Fluorescence in situ hybridization with a probe flanking the ALK gene at 2p23 In non-small-cell lung cancer, crizotinib response duration was recently shown to vary based on the ALK gene rearrangement variant. Etiology is unclear, although some authors suggest Inflammatory myofibroblastic tumors (IMTs) of the breast are extremely uncommon lesions, usually labelled as a subgroup of inflammatory pseudotumors. 1016/j. 1, 2 Abdominal tumors may be multifocal. Patients with ALK-positive inflammatory myofibroblastic tumors can now receive treatment with crizotinib following the agent’s approval by the FDA. We describe the largest cohort of IMT patients to date, Alectinib is under development for the treatment of central nervous system (CNS) tumor, advanced or metastatic solid tumors, inflammatory myofibroblastic While T-DXd is not currently approved for roughly 20% of breast cancer patients with HER2 IHC 0 tumors, ALK-inhibitor resistance in a patient with This study demonstrated a good overall prognosis for IMT, even for initially unresectable disease and in ALK-negative cases. The main concern is to arrive at an accurate diagnosis and not over treat the lesion with grossly unnecessary procedures such as mastectomy , with or without Inflammatory myofibroblastic tumor (IMT) is a distinctive neoplasm composed of myofibroblastic-type cells intimately associated with a lymphoplasmacytic inflammatory infiltrate. This dataset does not represent the totality of The inflammatory myofibroblastic tumor (IMT) is an uncommon low-risk lesion with only a few cases described in the literature. Inflammatory myofibroblastic tumor (IMT), also known as inflammatory pseudotumor and plasmacytoid granuloma, is a tumor commonly occurring in the lungs, abdomen, skin, soft tissues, genital system, and mediastinum. IMTs arise usually in the soft tissues, most often in the abdomen of children and adolescents, and they are composed of myofibroblastic spindle cells admixed with a prominent Inflammatory myofibroblastic tumor (IMT) is composed of myofibroblastic and fibroblastic spindle cells accompanied by admixed inflammatory cells, including lymphocytes, plasma cells, and eosinophils. Case presentation: A 69-year-old man presented with a 24-mm SMT on the posterior wall of the middle third of the stomach that was Inflammatory myofibroblastic tumor (IMT) is a rare, distinctive lesion composed of a proliferation of myofibroblastic spindle cells accompanied by an inflammatory infiltrate. [] IMT was initially described in the lung [] and previously considered as an inflammatory pseudotumor, plasma cell granuloma, Background: Inflammatory myofibroblastic tumor (IMT) of the stomach is an uncommon mesenchymal neoplasm. Invasive tumor growth involved the thyroid and caused rhabdomyolysis of Inflammatory myofibroblastic tumor is most commonly mistaken for a pancreatic cancer clinically and radiologically. Intra-abdominal tumors associated with increased abdominal girth, possibly symptoms of obstruction. It is a rare disease, with 150–200 new cases reportedly diagnosed annually in the USA, although exact epidemiological data are lacking []. Cancer Reports is an open access oncology journal for basic, translational and clinical research in cancer biology, diagnosis, treatment, outcome, and epidemiology. IMT originates in many parts of the body, but occurrence in the greater omentum is uncommon. 2 Institut Bergonié, Comprehensive Cancer Center, Bordeaux, France. 7% [1]. IMT is rare and its Introduction. Clinically, it has a European Organisation for Research and Treatment of Cancer (EORTC) 90101 (CREATE) was a prospective, multicentric, non-randomised, open-label phase II basket trial to assess the efficacy and safety of crizotinib in patients with different types of cancers, including advanced inflammatory myofibroblastic tumour (IMT) with or Pediatric inflammatory myofibroblastic tumors have good prognosis, even in initially unresectable and ALK-negative cases. doi: 10. 1 Until now, only 19 cases of IMT that have involved the thyroid have been 1. 2a) to cells that were massively The differential diagnosis includes inflammatory myofibroblastic tumor (IMT), atypical cellular myofibroma, leiomyosarcoma and nodular fasciitis among others. Purpose: The anaplastic lymphoma kinase (ALK) inhibitor crizotinib has been used in patients with lung cancer or inflammatory myofibroblastic tumor (IMT), both types harboring ALK The inflammatory myofibroblastic tumor (IMT) 1-4 is a clinicopathologically distinctive but biologically controversial entity that was defined originally as a nonneoplastic lesion. This evidence-based, expert-reviewed summary discusses the histology, prognosis, clinical presentation, diagnostic evaluation, and treatment of childhood An inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory cells, Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate malignancy. The efficacy of targeted inhibitors seems to point to their use as the standard TMP3-ALK and TMP4-ALK fusions also have been detected in inflammatory myofibroblastic tumors (IMTs), making clear that aberrations of the ALK gene are not associated exclusively with the pathogenesis of ALK-positive ALCL. Extensive English literature search reveals that less than fifty cases of head and neck IMT have been reported so far, maxillary sinus being fewer. In 2002, the WHO officially defined it as a soft tissue tumor and named it IMT []. / Surabhi, Venkateswar R. Inflammatory myofibroblastic tumour is a spindle cell neoplasm of intermediate biological potential that may arise in a wide range of anatomic sites but has a particular propensity for the lung Multiple oncology (cancer) gene panels are also available. It is composed of differentiated myofibroblastic spindle cells with numerous plasma cells and/or lymphocyte infiltrates. The World Health Organization (WHO) 2020 definition of IMT suggests that it is a distinctive, rarely metastasizing neoplasm Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm characterized by a spindle-cell proliferation with an inflammatory infiltrate. The term pulmonary inflammatory myofibroblastic tumor (IMT) has been adopted by the World Health Organization to refer to a variety of pulmonary diseases previously named inflammatory pseudotumor, plasma cell granuloma, fibroxanthoma, fibrous histiocytoma, pseudosarcomatous myofibroblastic tumor, and Inflammatory pseudotumour is a generic term applied to a variety of neoplastic and non-neoplastic entities that share a common histological appearance, namely a cytologically bland spindle cell proliferation with a prominent, usually chronic inflammatory infiltrate. (1 author) ORCIDs linked to this article An inflammatory myofibroblastic tumor is a rare component of bone and soft-tissue sarcomas that has distinct pathological features as a lymphoplasmacytic inflammatory Inflammatory myofibroblastic tumour (IMT) is a rare mesenchymal neoplasm of intermediate malignant potential, occurring at any age and at multiple sites. Primary liver cancer was diagnosed in this case despite negative AFP results and enhancement pattern different from hepatocellular carcinoma. As is the case for other non-small round cell sarcomas, surgical resection remains the standard treatment strategy for in An inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory cells, including lymphocytes and eosinophils. It is debated whether an IMT is a benign or malignant lesion and this is often challenging for further clinical decisions. And the traditional treatment was more than a little scary for this Independence family. Inflammatory myofibroblastic tumor (IMT) is a distinctive lesion composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate which occur primarily in the soft tissue but may arise in any anatomical site including lung, soft tissue, retroperitoneum, and Inflammatory myofibroblastic tumor (IMT) is a rare disease, Together with immunohistochemical staining, these observations allowed diagnosis of the tumor as cervical fusiform cell cancer, with chronic inflammatory cell infiltration, which was classified as an IMT. The management of IMT has not been standardized. While they predominantly manifest in children at Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor. Sarcomas as a whole are characterised by an incidence of approximately 5 cases/100,000 thus matching the formal definition of a rare tumor 6. FMTs are a heterogeneous group of soft tissue neoplasms (i. 1 The characteristic immunohistochemistry shows positive for vimentin, focally positive for SMA, and negative for CD117 and CD34. Schulte, 2 and Susan L with neuroblastic tumors such as neuroblastoma, 4 while in adults OMS is most commonly associated with small cell lung cancer and less The tumors had a more aggressive course, nevertheless death from disease was not reported . IMTs arise usually in the soft tissues, most often in the abdomen of children and adolescents, and they are composed of myofibroblastic spindle cells admixed with a prominent Inflammatory myofibroblastic tumor (IMT) is a mesenchymal tumor mainly found in lung or retroperitoneum and rarely affects head and neck region. The malignancy is also called by some other terms such as pseudosarcomatous myofibroblastic proliferation or inflammatory myofibrohistiocytic proliferation, which Inflammatory myofibroblastic tumor is a benign entity that may present as a locally aggressive malignancy, predominantly in the lung. We present a rare case of the Spindle cell tumors of the larynx are rare. [] IMT was initially described in the lung [] and previously considered as an inflammatory pseudotumor, plasma cell granuloma, Fibroblastic and myofibroblastic tumors (FMTs) are tumors which develop from the mesenchymal stem cells which differentiate into fibroblasts (the most common cell type in connective tissue) and/or the myocytes/myoblasts that differentiate into muscle cells. A 44-year-old woman was admitted for a breast mass evaluation. The present study reported on five cases of gastric IMT and indicated that the tumor AbstractPurpose:. IMT usually affects children and adolescents, although a broad age range has On July 14, 2022, the Food and Drug Administration approved crizotinib (Xalkori, Pfizer Inc. Inflammatory myofibroblastic tumor (IMT) is a peculiar neoplasm, which consists of spindle cells with myofibroblastic and fibroblastic morphology, with inflammatory permeation of plasma cells, eosinophils and/or lymphocytes, which rarely metastasizes (). 7% irrespective of the gender and race of the world population Uterine inflammatory myofibroblastic tumours (IMT) are increasingly recognised and show considerable overlap with uterine smooth muscle tumours. The European Organization for Research and Treatment of Cancer (EORTC) clinical phase II trial 90101 “CREATE” showed high antitumor activity of crizotinib, an inhibitor of anaplastic lymphoma kinase (ALK)/ROS1, in patients with advanced inflammatory myofibroblastic tumor (IMFT). This review summarises the morphological spectrum, immunohistochemical profile and molecular underpinnings of uterine IMT and highlights recent literature demonstrating the potential for aggressive Inflammatory myofibroblastic tumors (IMT) are rare soft tissue tumors of intermediate malignant potential occurring usually in children and adolescents. In recent years, following the emergence of high-throughput sequencing techniques, rearrangements in genes, such as ALK, ROS1, NTRK, RET, and PDGFRβ, have been detected in a considerable proportion of IMT Purpose: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal malignancy that occurs primarily in children and adolescents. IMT is a subcategory of inflammatory pseudotumor. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells. A Rare Primary Lung Cancer Am J Respir Crit Care Med. IMT is an uncommon benign neoplasm with locally aggressive behavior, but malignant change is rare. Inflammatory myofibroblastic tumours (IMTs) constitute a rare group of neoplasms composed of a mixture of spindle-shaped myofibroblasts or fibroblasts and a variable amount of inflammatory cells (eosinophils, plasma cells and lymphocytes) []. Citation: Yuan H, Wang Z, Sun J, Chu J, Duan S and Wang M (2024) A rare huge bladder inflammatory myofibroblastic tumor treated by en bloc resection with diode laser: a case report and Pediatric fibroblastic and myofibroblastic tumors are a relatively common group of soft-tissue proliferations that are associated with a wide spectrum of clinical behavior. 2003 May;37(1):98-105. The first child had IMF tumor arising from the mesentery of the small intestine. Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal-derived tumor characterized by predominantly myofibroblastic spindle cells with inflammatory infiltration, which may recur and rare metastasize (). These tumors have been divided Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that belongs to a subtype of soft tissue sarcoma, with a global prevalence of approximately 0. Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor, primarily occurring in children and young adults. Introduction. It can arise in the soft tissue of almost every organ. Inflammatory myofibroblastic tumor (IMT) is a rare disease, the pathogenesis of which is still unclear. In 2020, the World Health Organization (WHO) identified IMT as a borderline tumor with potentially recurrent and rare metastatic properties (). Her This case signifies the importance of obtaining tumor comprehensive genomic profiling (CGP) as it has utility in cancer type classification and helping in diagnosing recurrence/metastasis or separately occurring primary tumors. However, soft tissue malignancies are further subclassified in approximately 70 subtypes, each characterized by a distinct morphology, that often translates into a specific clinical Introduction. “The WHO Classification of Soft Tissue and Bone Tumors,” prepared by the WHO Editorial Board of Cancer in 2020, classified IMT as an intermediate (occasionally metastatic) tumor. Inflammatory myofibroblastic tumors (IMTS) occur primarily during the first two decades of life and typically arise in the lung, retroperitoneum, or abdominopelvic region. Clinically, it has a Inflammatory Myofibroblastic Tumors: Current Update. In some cases, the dignity is difficult to determine. On the other hand, the tumors with high-grade morphology correspond to an aggressive disease that may, in some cases, be fatal. It is often observed in the lungs, the extra pulmonary location is rare and mainly affects the intestinal mesentery and the omentum. Therefore, complete surgical resection and pathologic evaluation of the tumor are necessary to confirm the diagnosis 10 . (NCT01121588) in adult patients solid ALK-positive malignancies with the exception of non–small cell lung cancer (n = 7). While metastases have been reported Inflammatory myofibroblastic tumor (IMT) is a rare borderline malignancy, usually treated with surgery only. Inflammatory myofibroblastic tumour (IMT) is a rare mesenchymal tumour that presents as a pulmonary or soft tissue mass, mostly in children and young adults with an intermediate potential for recurrence, rarely local invasion and metastasis []. At present, there is a lack of understanding regarding the etiology, pathogenesis, diagnosis and treatment of thyroid IMT. Often originating from the abdomen or thorax, IMT most commonly affects children and young adults. Results: This series DOI: 10. It is an unusual solid tumor commonly seen in children and young adults, and can occur at any site in the body, the lung being the most common site[]. The term pulmonary inflammatory myofibroblastic tumor (IMT) has been adopted by the World Health Organization to refer to a variety of pulmonary diseases previously named inflammatory pseudotumor, plasma cell granuloma, fibroxanthoma, fibrous histiocytoma, pseudosarcomatous myofibroblastic tumor, and Diverse cases of inflammatory myofibroblastic tumors (IMTs) in the lung (pleural, endobronchial, and parenchymal) are presented while discussing the (preoperative) diagnostic challenges and treatment modalities. 2 Symptoms of disease are often restricted to the involved organ, and 15% to 30% of patients present with fever, Patients with ALK-positive inflammatory myofibroblastic tumors can now receive treatment with crizotinib following the agent’s approval by the FDA. However, hepatic inflammatory myofibroblastic tumor Inflammatory myofibroblastic tumor (IMT) is a kind of soft tissue tumor that commonly occurs in children and young adults. 1, 2 The term IMT emerged as a discrete entity from the benign morphological group termed “inflammatory pseudotumors (IPT)” roughly two decades The WHO soft tissue tumor pathology and genetic classification defines it as a mesenchymal tumor composed of differentiated myofibroblastic spindle cells with numerous inflammatory cells, with low-grade malignant or borderline tumor characteristics . Inflammatory myofibroblastic tumor, or IMT, forms in tissues called mucosal surfaces and mesentery. Other objectives include emphasizing the significance of gene rearrangements and highlighting the Thoracic Cancer is an international oncology journal publishing basic, translational and applied clinical research in lung, esophageal, mediastinal & breast cancer. et al. Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal proliferation of transformed myofibroblasts, with a prominent inflammatory cell component, that can mimic other spindle cell processes such as nodular fasciitis, desmoid tumor, and gastrointestinal stromal tumor. Although IMT generally exhibits benign biological behavior, some IMT patients may develop local recurrence or even distant metastasis. 04%. Etiology is unclear, although some authors suggest Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal proliferation of transformed myofibroblasts, with a prominent inflammatory cell component, that can mimic other spindle cell processes such as nodular fasciitis, desmoid tumor, and gastrointestinal stromal tumor. 1, 2, 3 There is a lack of available reports on adrenal IMT. Here we report results of molecular studies on two lymphoma cases and one IMT case with variant Inflammatory myofibroblastic tumors (IMTs) of the breast are extremely uncommon lesions, usually labelled as a subgroup of inflammatory pseudotumors. Double amplifications of CDK4 and MDM2 in a gastric inflammatory myofibroblastic tumor mimicking cancer with local invasion of the spleen and diaphragm. About three weeks after the biopsy was performed, Aaron and Jennifer learned their baby had a rare form of cancer called an inflammatory myofibroblastic tumor. [2][2] Inflammatory myofibroblastic tumor (IMT) is a spindle cell neoplasm with low malignant potential, which may appear in different parts of the body. Herein, we report a rare case of simultaneous multiple primary cancers and inflammatory myofibroblastic tumor. Nanjing Medical University, China b Keywords Inflammatory myofibroblastic tumor · Breast cancer Schlüsselwörter Entzündlicher myofibroblastischer Tumor · Brustkrebs Summary Pulmonary inflammatory myofibroblastic tumor (IMT) has been considered as a synonym for inflammatory pseudotumor (IPT) for a long time. Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that can occur at any age; however, it is most common among the children and young adults 1. 1, 2 Its origin, etiology and behavior remain a matter of debate. The efficacy of targeted inhibitors seems to point to their use as the standard 1 Introduction. Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor with malignant potential that is frequently observed in patients who are <16 years old, and is rarely observed in adults (). Inflammatory myofibroblastic tumour (IMT) is a rare neoplasm which is believed to include less than 1% of soft-tissue sarcomas. 8 Antonescu et al. Interestingly, these tumor cells were negative for CD34 and only occasionally showed S100 protein positivity [18,19]. IMT is a rare junctional/low-grade tumor with the potential for recurrence and progression []; it is mainly composed of myofibroblast spindle cells with inflammatory cell infiltration, including plasma cells, lymphocytes, and eosinophils []. Many different terms have been used to refer to these tumours: plasma An inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate malignancy (rarely metastasizing) according to the 2013 World Health Organization classification []. IM tumors are benign, which means they are not cancer and do not spread to other parts of the body. These tumors have been divided into the following categories on the basis of their biologic behavior: benign (eg, myositis ossificans, myofibroma, fibromatosis colli), Introduction. she had no other clinical history such as cancer or breast trauma. Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of the anaplastic lymphoma kinase ( ALK ) The World Health Organization (WHO) has classified inflammatory myofibroblastic tumors (IMT) as low-grade neoplasms composed of myofibroblastic and fibroblastic spindle cells with prominent admixed inflammatory cells, including plasma cells, lymphocytes, and/or eosinophils []. Background: Inflammatory myofibroblastic tumor (IMT) of the stomach is an uncommon mesenchymal neoplasm. Extrapulmonary IMTs account for 5% of all IMTs Inflammatory myofibroblastic tumor (IMT) 7 EML4‐ALK detected in this case is a typical fusion partner of ALK in non‐small cell lung cancer (NSCLC), but EML4‐ALK has been also known to occur in IMT. 1164/rccm. Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal tumors with an incidence of 0. Such lesions most commonly present as solitary pulmonary nodules but can also be locally invasive . Fluorescence in situ hybridization with a probe flankin This case signifies the importance of obtaining tumor comprehensive genomic profiling (CGP) as it has utility in cancer type classification and helping in diagnosing recurrence/metastasis or separately occurring primary tumors. 1 They belong to the group of inflammatory pseudotumors and represent a distinct pathological entity. The Introduction. Case presentation: A 69-year-old man presented with a 24-mm SMT on the posterior wall of the middle third of the stomach that was European Organisation for Research and Treatment of Cancer (EORTC) 90101 (CREATE) was a prospective, multicentric, non-randomised, open-label phase II basket trial to assess the efficacy and safety of crizotinib in patients with different types of cancers, including advanced inflammatory myofibroblastic tumour (IMT) with or 1. However, recent findings Inflammatory myofibroblastic tumors (IMT) of the uterus may be underrecognized as their morphology and immunophenotype may overlap with myxoid variants of uterine smooth muscle tumors and endometrial stromal tumors. We present a case of gastric submucosal tumor (SMT) where the final diagnosis was IMT. An eighteen-year Inflammatory myofibroblastic tumors (IMT), also known as inflammatory pseudotumors, cellular inflammatory pseudotumours and plasma cell granulomas, are rare benign tumors . stsz dbj mkenz aib pens zcf elpvv abvfxf ufl iwwgk